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The 2021 Russian Federation National Award in Science and Technology has been presented to Alexander ARCHAKOV and Andrei LISITSA for a series of experimental and theoretical studies on the medical proteomics of membrane and chromosome-centric groups of proteins.

Alexander Archakov was born in the city of Kashin, Tver Region, on January 10, 1940. PhD (Biology), Professor, Member of Russian Academy of Sciences. Academic Supervisor at the Orekhovich Research Institute of Biomedical Chemistry.

Andrei Lisitsawas born in Moscow on July 1, 1976. PhD (Biology) and Member of Russian Academy of Sciences. Senior Fellow at the Orekhovich Research Institute of Biomedical Chemistry.

The achievement is in deciphering the human proteome, which allowed to develop technology for evaluating patient health. The scientists determined the biomarkers of pathological conditions by applying the chromosome-centric approach to the study of proteome. For the first time in history, they detected single copies of molecules – early signs of an illness – in one microliter of blood.

Dr Lisitsa developed an experimental computing method, From Genome to Medication, by combining data from genomics, proteomics and metabolomics. He modeled the molecular structures of modified proteins and phospholipids.

Dr Archakov oversaw the development of medications and testing laboratory diagnostic facilities that make it possible to reveal the early stages of oncological and neurodegenerative diseases.

The researchers combined the potentialities of ultra-sensitive molecular detectors with nano-production of medications. In practical terms, their work led to the development and manufacture of new medications: Fosfogliv – for treating liver ailments and Vitafosfolip – for treating atherosclerosis.

The 2021 Russian Federation National Award in Science and Technology has been presented to David ZARIDZE, Ivan STILIDI and Alexander RUMYANTSEV for the development and production of preventive and clinical technology to reduce the morbidity and mortality rates of the population, to improve a patient’s quality of life, and for achieving tangible progress in Russia’s demographic situation.

David Zaridze was born in Tbilisi (Georgian SSR) on January 9, 1941. PhD (Medicine), Professor, RAS Corresponding Member. Head of the Department for Analysing Tumour Epidemiology in the Regions at the Centre for Coordinating Oncological Care at the Blokhin National Medical Oncological Research Centre under the Ministry of Health.

Ivan Stilidi was born in Sukhumi on April 1, 1964 (Abkhazian ASSR). PhD (Medicine), Professor, Member of Russian Academy of Sciences. Director of the Blokhin National Medical Oncological Research Centre under the Ministry of Health.

Alexander Rumyantsev was born in Novo-Georgiyevsk, Kirovograd Region (Ukrainian SSR) on February 12, 1947. PhD (Medicine), Professor, Member of Russian Academy of Sciences. Academic Supervisor at the Rogachev National Medical Research Centre for Children’s Hematology, Oncology and Immunology under the Ministry of Health.

The team of researchers presented a unique, large-scale and multi-faceted clinical-epidemiological project that covers research in oncology, epidemiology, oncohematology and immunology in adults and children.

The results of their research are a major factor in improving the demographic situation in Russia.

David Zaridze made a substantial contribution to developing population-based and clinical epidemiology in chronic non-infectious diseases. Having studied regional peculiarities of the incidence of malicious tumours and conducted analytical epidemiological research, Dr Zaridze identified environmental factors and lifestyles that can influence the morbidity and mortality rate from malicious tumours and other chronic non-commutable ailments.

Ivan Stilidi developed innovative methods for the surgical treatment of tumours in the abdominal cavity and retroperitoneum. He showed that patient survival rates and quality of life parameters directly depend on scientifically substantiated methods of surgical strategies based on the balance between a radical approach and organ-preserving surgery.

Alexander Rumyantsev is the founder of the domestic Oncohematology Clinical Department and Research School. He made a valuable contribution to developing preventive care and therapy for children’s diseases, which helped to considerably reduce children’s mortality rate in Russia.

The 2021 Russian Federation National Award in Science and Technology has been presented to Vladimir TRAVUSH for world class achievements in unique high-rise construction as a result of his developments in the building sciences and technologies in Russia.

Vladimir Travush was born in Dnepropetrovsk on May 4, 1936. PhD (Technical Sciences), Professor. Chief Designer and Deputy Director at the Urban Project Institute of Residential and Public Buildings (Moscow).

Mr Travush made a significant contribution to domestic and global science in a number of areas: construction mechanics, mathematical calculations of building structures, improvement of various types of ferroconcrete, monolithic, metal and wood structures and the development of innovative high-rise construction technology.

His scientific achievements made it possible to create breakthrough technology for high-rise construction. They embrace a wide range of new technologies: automated monitoring of deformations in support structures and foundations in buildings and other structures; methods of calculating wind load on high-rise buildings and structures; calculating methods for wooden, ferroconcrete and steel structures, including elastic base structures and those made of multi-layered glass; scientific foundations for earthquake resistance in construction; standards and guidelines for designing high-rise buildings and centres; the development of the theory of durability of structural design in buildings and the protection of buildings and structures from progressive collapse.

Vladimir Travush has designed over 70 projects including unique structures in the late 20^th and early 21^st centuries: the Ostankino TV Tower (erected in Moscow in 1967 and rebuilt after a fire in 2006); the Trade Union Sports Palace (Arkhangelsk, 1980); the Dynamo Olympic Sports Palace (Moscow, 1980); the large-span Sports Palace (Tver, 1982), the Ho Chi Minh Museum (Hanoi, 1990) Indoor Market (Rzhev, 1990); the Moskvorechiye Sports Complex (Moscow, 1993); the Bagration Bridge across the Moskva River as part of the Moscow City International Business Centre (Moscow, 1970); the Tower 2000 Administrative Office in Moscow City Centre (Moscow, 2001); the Indoor Ice Skating Centre in Krylatskoye (Moscow, 2004), to name a few.